Fast adaptation in vestibular hair cells requires myosin-1c activity.
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ABSTRACT:
SUBMITTER: Stauffer EA
PROVIDER: S-EPMC2682556 | biostudies-literature | 2005 Aug
REPOSITORIES: biostudies-literature
Publications
Fast adaptation in vestibular hair cells requires myosin-1c activity.
Stauffer Eric A EA Scarborough John D JD Hirono Moritoshi M Miller Emilie D ED Shah Kavita K Mercer John A JA Holt Jeffrey R JR Gillespie Peter G PG
Neuron 20050801 4
In sensory hair cells of the inner ear, mechanical amplification of small stimuli requires fast adaptation, the rapid closing of mechanically activated transduction channels. In frog and mouse vestibular hair cells, we found that the rate of fast adaptation depends on both channel opening and stimulus size and that it is modeled well as a release of a mechanical element in series with the transduction apparatus. To determine whether myosin-1c molecules of the adaptation motor are responsible for ...[more]
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