Ontology highlight
ABSTRACT:
SUBMITTER: Singhal SS
PROVIDER: S-EPMC2683040 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Singhal Sharad S SS Roth Cherice C Leake Kathryn K Singhal Jyotsana J Yadav Sushma S Awasthi Sanjay S
Biochemical pharmacology 20081125 6
RLIP76 plays a central role in radiation and chemotherapy resistance through its activity as a multi-specific ATP-dependent transporter which is over-expressed in a number of types of cancers. RLIP76 appears to be necessary for cancer cell survival because both in vitro cell culture and in vivo animal tumor studies show that depletion or inhibition of RLIP76 causes selective toxicity in malignant cells. RLIP76 induces apoptosis in cancer cells through the accumulation of endogenously formed GS-E ...[more]