Ontology highlight
ABSTRACT:
SUBMITTER: Carulla N
PROVIDER: S-EPMC2683116 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Carulla Natàlia N Zhou Min M Arimon Muriel M Gairí Margarida M Giralt Ernest E Robinson Carol V CV Dobson Christopher M CM
Proceedings of the National Academy of Sciences of the United States of America 20090428 19
Recent experimental evidence points to intermediates populated during the process of amyloid fibril formation as the toxic moieties primarily responsible for the development of increasingly common disorders such as Alzheimer's disease and type II diabetes. We describe here the application of a pulse-labeling hydrogen-deuterium (HD) exchange strategy monitored by mass spectrometry (MS) and NMR spectroscopy (NMR) to characterize the aggregation process of an SH3 domain under 2 different conditions ...[more]