Ontology highlight
ABSTRACT:
SUBMITTER: Barlow JH
PROVIDER: S-EPMC2683695 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Barlow Jacqueline H JH Rothstein Rodney R
The EMBO journal 20090305 8
Recruitment of the homologous recombination machinery to sites of double-strand breaks is a cell cycle-regulated event requiring entry into S phase and CDK1 activity. Here, we demonstrate that the central recombination protein, Rad52, forms foci independent of DNA replication, and its recruitment requires B-type cyclin/CDK1 activity. Induction of the intra-S-phase checkpoint by hydroxyurea (HU) inhibits Rad52 focus formation in response to ionizing radiation. This inhibition is dependent upon Me ...[more]