Ontology highlight
ABSTRACT:
SUBMITTER: Ardehali MB
PROVIDER: S-EPMC2683705 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Ardehali M Behfar MB Yao Jie J Adelman Karen K Fuda Nicholas J NJ Petesch Steven J SJ Webb Watt W WW Lis John T JT
The EMBO journal 20090312 8
Several eukaryotic transcription factors have been shown to modulate the elongation rate of RNA polymerase II (Pol II) on naked or chromatin-reconstituted templates in vitro. However, none of the tested factors have been shown to directly affect the elongation rate of Pol II in vivo. We performed a directed RNAi knock-down (KD) screen targeting 141 candidate transcription factors and identified multiple factors, including Spt6, that alter the induced Hsp70 transcript levels in Drosophila S2 cell ...[more]