Tissue specificity and the human protein interaction network.
Ontology highlight
ABSTRACT:
SUBMITTER: Bossi A
PROVIDER: S-EPMC2683721 | biostudies-literature | 2009
REPOSITORIES: biostudies-literature
Publications
Tissue specificity and the human protein interaction network.
Molecular systems biology 20090407
A protein interaction network describes a set of physical associations that can occur between proteins. However, within any particular cell or tissue only a subset of proteins is expressed and so only a subset of interactions can occur. Integrating interaction and expression data, we analyze here this interplay between protein expression and physical interactions in humans. Proteins only expressed in restricted cell types, like recently evolved proteins, make few physical interactions. Most tiss ...[more]
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