Ontology highlight
ABSTRACT:
SUBMITTER: Netzer R
PROVIDER: S-EPMC6290019 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Netzer Ravit R Listov Dina D Lipsh Rosalie R Dym Orly O Albeck Shira S Knop Orli O Kleanthous Colin C Fleishman Sarel J SJ
Nature communications 20181211 1
Protein networks in all organisms comprise homologous interacting pairs. In these networks, some proteins are specific, interacting with one or a few binding partners, whereas others are multispecific and bind a range of targets. We describe an algorithm that starts from an interacting pair and designs dozens of new pairs with diverse backbone conformations at the binding site as well as new binding orientations and sequences. Applied to a high-affinity bacterial pair, the algorithm results in 1 ...[more]