NKX2-5 regulates the expression of beta-catenin and GATA4 in ventricular myocytes.
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ABSTRACT:
SUBMITTER: Riazi AM
PROVIDER: S-EPMC2684637 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Publications
NKX2-5 regulates the expression of beta-catenin and GATA4 in ventricular myocytes.
Riazi Ali M AM Takeuchi Jun K JK Hornberger Lisa K LK Zaidi Syed Hassan SH Amini Fariba F Coles John J Bruneau Benoit G BG Van Arsdell Glen S GS
PloS one 20090528 5
<h4>Background</h4>The molecular pathway that controls cardiogenesis is temporally and spatially regulated by master transcriptional regulators such as NKX2-5, Isl1, MEF2C, GATA4, and beta-catenin. The interplay between these factors and their downstream targets are not completely understood. Here, we studied regulation of beta-catenin and GATA4 by NKX2-5 in human fetal cardiac myocytes.<h4>Methodology/principal findings</h4>Using antisense inhibition we disrupted the expression of NKX2-5 and st ...[more]
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