Molecular evolution of the junctophilin gene family.
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ABSTRACT:
SUBMITTER: Garbino A
PROVIDER: S-EPMC2685503 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Publications
Molecular evolution of the junctophilin gene family.
Garbino Alejandro A van Oort Ralph J RJ Dixit Sayali S SS Landstrom Andrew P AP Ackerman Michael J MJ Wehrens Xander H T XH
Physiological genomics 20090324 3
Junctophilins (JPHs) are members of a junctional membrane complex protein family important for the physical approximation of plasmalemmal and sarcoplasmic/endoplasmic reticulum membranes. As such, JPHs facilitate signal transduction in excitable cells between plasmalemmal voltage-gated calcium channels and intracellular calcium release channels. To determine the molecular evolution of the JPH gene family, we performed a phylogenetic analysis of over 60 JPH genes from over 40 species and compared ...[more]
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