Ontology highlight
ABSTRACT:
SUBMITTER: Novak U
PROVIDER: S-EPMC2686142 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Novak Urban U Rinaldi Andrea A Kwee Ivo I Nandula Subhadra V SV Rancoita Paola M V PM Compagno Mara M Cerri Michaela M Rossi Davide D Murty Vundavalli V VV Zucca Emanuele E Gaidano Gianluca G Dalla-Favera Riccardo R Pasqualucci Laura L Bhagat Govind G Bertoni Francesco F
Blood 20090303 20
Unique and shared cytogenetic abnormalities have been documented for marginal zone lymphomas (MZLs) arising at different sites. Recently, homozygous deletions of the chromosomal band 6q23, involving the tumor necrosis factor alpha-induced protein 3 (TNFAIP3, A20) gene, a negative regulator of NF-kappaB, were described in ocular adnexal MZL, suggesting a role for A20 as a tumor suppressor in this disease. Here, we investigated inactivation of A20 by DNA mutations or deletions in a panel of extran ...[more]