Ontology highlight
ABSTRACT:
SUBMITTER: Stefansson H
PROVIDER: S-EPMC2687075 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Stefansson Hreinn H Rujescu Dan D Cichon Sven S Pietiläinen Olli P H OP Ingason Andres A Steinberg Stacy S Fossdal Ragnheidur R Sigurdsson Engilbert E Sigmundsson Thordur T Buizer-Voskamp Jacobine E JE Hansen Thomas T Jakobsen Klaus D KD Muglia Pierandrea P Francks Clyde C Matthews Paul M PM Gylfason Arnaldur A Halldorsson Bjarni V BV Gudbjartsson Daniel D Thorgeirsson Thorgeir E TE Sigurdsson Asgeir A Jonasdottir Adalbjorg A Jonasdottir Aslaug A Bjornsson Asgeir A Mattiasdottir Sigurborg S Blondal Thorarinn T Haraldsson Magnus M Magnusdottir Brynja B BB Giegling Ina I Möller Hans-Jürgen HJ Hartmann Annette A Shianna Kevin V KV Ge Dongliang D Need Anna C AC Crombie Caroline C Fraser Gillian G Walker Nicholas N Lonnqvist Jouko J Suvisaari Jaana J Tuulio-Henriksson Annamarie A Paunio Tiina T Toulopoulou Timi T Bramon Elvira E Di Forti Marta M Murray Robin R Ruggeri Mirella M Vassos Evangelos E Tosato Sarah S Walshe Muriel M Walshe Muriel M Li Tao T Vasilescu Catalina C Mühleisen Thomas W TW Wang August G AG Ullum Henrik H Djurovic Srdjan S Melle Ingrid I Olesen Jes J Kiemeney Lambertus A LA Franke Barbara B Sabatti Chiara C Freimer Nelson B NB Gulcher Jeffrey R JR Thorsteinsdottir Unnur U Kong Augustine A Andreassen Ole A OA Ophoff Roel A RA Georgi Alexander A Rietschel Marcella M Werge Thomas T Petursson Hannes H Goldstein David B DB Nöthen Markus M MM Peltonen Leena L Collier David A DA St Clair David D Stefansson Kari K
Nature 20080901 7210
Reduced fecundity, associated with severe mental disorders, places negative selection pressure on risk alleles and may explain, in part, why common variants have not been found that confer risk of disorders such as autism, schizophrenia and mental retardation. Thus, rare variants may account for a larger fraction of the overall genetic risk than previously assumed. In contrast to rare single nucleotide mutations, rare copy number variations (CNVs) can be detected using genome-wide single nucleot ...[more]