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A novel nitroreductase of Staphylococcus aureus with S-nitrosoglutathione reductase activity.

ABSTRACT: In this report we show that inactivation of the putative nitroreductase SA0UHSC_00833 (ntrA) increases the sensitivity of Staphylococcus aureus to S-nitrosoglutathione (GSNO) and augments its resistance to nitrofurans. S. aureus NtrA is a bifunctional enzyme that exhibits nitroreductase and GSNO reductase activity. A phylogenetic analysis suggests that NtrA is a member of a novel family of nitroreductases that seems to play a dual role in vivo, promoting nitrofuran activation and protecting the cell against transnitrosylation.

SUBMITTER: Tavares AF

PROVIDER: S-EPMC2687171 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature

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A novel nitroreductase of Staphylococcus aureus with S-nitrosoglutathione reductase activity.

Tavares Ana Filipa N AF Nobre Lígia S LS Melo Ana M P AM Saraiva Lígia M LM

Journal of bacteriology 20090313 10

In this report we show that inactivation of the putative nitroreductase SA0UHSC_00833 (ntrA) increases the sensitivity of Staphylococcus aureus to S-nitrosoglutathione (GSNO) and augments its resistance to nitrofurans. S. aureus NtrA is a bifunctional enzyme that exhibits nitroreductase and GSNO reductase activity. A phylogenetic analysis suggests that NtrA is a member of a novel family of nitroreductases that seems to play a dual role in vivo, promoting nitrofuran activation and protecting the ...[more]

PMID: 19286809

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