Ontology highlight
ABSTRACT:
SUBMITTER: Yang Z
PROVIDER: S-EPMC3070165 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Yang Zhiyong Z Wang Zhi-En ZE Doulias Paschalis-Thomas PT Wei Wei W Ischiropoulos Harry H Locksley Richard M RM Liu Limin L
Journal of immunology (Baltimore, Md. : 1950) 20101027 11
NO is critical to immunity, but its role in the development of the immune system is unknown. In this study, we show that S-nitrosoglutathione reductase (GSNOR), a protein key to the control of protein S-nitrosylation, is important for the development of lymphocytes. Genetic deletion of GSNOR in mice results in significant decrease in both T and B lymphocytes in the periphery. In thymus, GSNOR deficiency causes excessive protein S-nitrosylation, increases apoptosis, and reduces the number of CD4 ...[more]