Ontology highlight
ABSTRACT:
SUBMITTER: Blow JJ
PROVIDER: S-EPMC2688777 | biostudies-literature | 2005 Jun
REPOSITORIES: biostudies-literature
Blow J Julian JJ Dutta Anindya A
Nature reviews. Molecular cell biology 20050601 6
To ensure its duplication, chromosomal DNA must be precisely duplicated in each cell cycle, with no sections left unreplicated, and no sections replicated more than once. Eukaryotic cells achieve this by dividing replication into two non-overlapping phases. During late mitosis and G1, replication origins are 'licensed' for replication by loading the minichromosome maintenance (Mcm) 2-7 proteins to form a pre-replicative complex. Mcm2-7 proteins are then essential for initiating and elongating re ...[more]