Ontology highlight
ABSTRACT:
SUBMITTER: Song L
PROVIDER: S-EPMC2689106 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Song Liping L Asgharzadeh Shahab S Salo Jill J Engell Kelly K Wu Hong-wei HW Sposto Richard R Ara Tasnim T Silverman Ayaka M AM DeClerck Yves A YA Seeger Robert C RC Metelitsa Leonid S LS
The Journal of clinical investigation 20090601 6
Tumor infiltration with Valpha24-invariant NKT cells (NKTs) associates with favorable outcome in neuroblastoma and other cancers. Although NKTs can be directly cytotoxic against CD1d+ cells, the majority of human tumors are CD1d-. Therefore, the role of NKTs in cancer remains largely unknown. Here, we demonstrate that CD68+ tumor-associated monocytes/macrophages (TAMs) represented the majority of CD1d-expressing cells in primary human neuroblastomas. TAMs stimulated neuroblastoma growth in human ...[more]