Ontology highlight
ABSTRACT:
SUBMITTER: Tokudome S
PROVIDER: S-EPMC2689117 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Tokudome Satori S Sano Motoaki M Shinmura Ken K Matsuhashi Tomohiro T Morizane Shintaro S Moriyama Hidenori H Tamaki Kayoko K Hayashida Kentaro K Nakanishi Hiroki H Yoshikawa Noritada N Shimizu Noriaki N Endo Jin J Katayama Takaharu T Murata Mitsushige M Yuasa Shinsuke S Kaneda Ruri R Tomita Kengo K Eguchi Naomi N Urade Yoshihiro Y Asano Koichiro K Utsunomiya Yasunori Y Suzuki Takeshi T Taguchi Ryo R Tanaka Hirotoshi H Fukuda Keiichi K
The Journal of clinical investigation 20090518 6
Lipocalin-type prostaglandin D synthase (L-PGDS), which was originally identified as an enzyme responsible for PGD2 biosynthesis in the brain, is highly expressed in the myocardium, including in cardiomyocytes. However, the factors that control expression of the gene encoding L-PGDS and the pathophysiologic role of L-PGDS in cardiomyocytes are poorly understood. In the present study, we demonstrate that glucocorticoids, which act as repressors of prostaglandin biosynthesis in most cell types, up ...[more]