Ontology highlight
ABSTRACT:
SUBMITTER: Chenoweth DM
PROVIDER: S-EPMC2689155 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Chenoweth David M DM Harki Daniel A DA Phillips John W JW Dose Christian C Dervan Peter B PB
Journal of the American Chemical Society 20090501 20
Hairpin pyrrole-imidazole (Py-Im) polyamides are a class of cell-permeable DNA-binding small molecules that can disrupt transcription factor-DNA binding and regulate endogenous gene expression. The covalent linkage of antiparallel Py-Im ring pairs with an gamma-amino acid turn unit affords the classical hairpin Py-Im polyamide structure. Closing the hairpin with a second turn unit yields a cyclic polyamide, a lesser-studied architecture mainly attributable to synthetic inaccessibility. We have a ...[more]