Ontology highlight
ABSTRACT:
SUBMITTER: Eberle AB
PROVIDER: S-EPMC2689704 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
PLoS biology 20080401 4
Translation termination at premature termination codons (PTCs) triggers degradation of the aberrant mRNA, but the mechanism by which a termination event is defined as premature is still unclear. Here we show that the physical distance between the termination codon and the poly(A)-binding protein PABPC1 is a crucial determinant for PTC recognition in human cells. "Normal" termination codons can trigger nonsense-mediated mRNA decay (NMD) when this distance is extended; and vice versa, NMD can be s ...[more]