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Regulation of slow and fast muscle myofibrillogenesis by Wnt/beta-catenin and myostatin signaling.


ABSTRACT: Deviation from proper muscle development or homeostasis results in various myopathic conditions. Employing genetic as well as chemical intervention, we provide evidence that a tight regulation of Wnt/beta-catenin signaling is essential for muscle fiber growth and maintenance. In zebrafish embryos, gain-of-Wnt/beta-catenin function results in unscheduled muscle progenitor proliferation, leading to slow and fast muscle hypertrophy accompanied by fast muscle degeneration. The effects of Wnt/beta-catenin signaling on fast muscle hypertrophy were rescued by misexpression of Myostatin or p21(CIP/WAF), establishing an in vivo regulation of myofibrillogenesis by Wnt/beta-catenin signaling and Myostatin. Epistatic analyses suggest a possible genetic interaction between Wnt/beta-catenin and Myostatin in regulation of slow and fast twitch muscle myofibrillogenesis.

SUBMITTER: Tee JM 

PROVIDER: S-EPMC2690692 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature

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Regulation of slow and fast muscle myofibrillogenesis by Wnt/beta-catenin and myostatin signaling.

Tee Jin-Ming JM   van Rooijen Carina C   Boonen Rick R   Zivkovic Danica D  

PloS one 20090611 6


Deviation from proper muscle development or homeostasis results in various myopathic conditions. Employing genetic as well as chemical intervention, we provide evidence that a tight regulation of Wnt/beta-catenin signaling is essential for muscle fiber growth and maintenance. In zebrafish embryos, gain-of-Wnt/beta-catenin function results in unscheduled muscle progenitor proliferation, leading to slow and fast muscle hypertrophy accompanied by fast muscle degeneration. The effects of Wnt/beta-ca  ...[more]

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