Ontology highlight
ABSTRACT:
SUBMITTER: Tee JM
PROVIDER: S-EPMC2690692 | biostudies-literature | 2009
REPOSITORIES: biostudies-literature
Tee Jin-Ming JM van Rooijen Carina C Boonen Rick R Zivkovic Danica D
PloS one 20090611 6
Deviation from proper muscle development or homeostasis results in various myopathic conditions. Employing genetic as well as chemical intervention, we provide evidence that a tight regulation of Wnt/beta-catenin signaling is essential for muscle fiber growth and maintenance. In zebrafish embryos, gain-of-Wnt/beta-catenin function results in unscheduled muscle progenitor proliferation, leading to slow and fast muscle hypertrophy accompanied by fast muscle degeneration. The effects of Wnt/beta-ca ...[more]