Ontology highlight
ABSTRACT:
SUBMITTER: Grillet N
PROVIDER: S-EPMC2691393 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Grillet Nicolas N Xiong Wei W Reynolds Anna A Kazmierczak Piotr P Sato Takashi T Lillo Concepcion C Dumont Rachel A RA Hintermann Edith E Sczaniecka Anna A Schwander Martin M Williams David D Kachar Bechara B Gillespie Peter G PG Müller Ulrich U
Neuron 20090501 3
In hair cells, mechanotransduction channels are gated by tip links, the extracellular filaments that consist of cadherin 23 (CDH23) and protocadherin 15 (PCDH15) and connect the stereocilia of each hair cell. However, which molecules mediate cadherin function at tip links is not known. Here we show that the PDZ-domain protein harmonin is a component of the upper tip-link density (UTLD), where CDH23 inserts into the stereociliary membrane. Harmonin domains that mediate interactions with CDH23 and ...[more]