Ontology highlight
ABSTRACT:
SUBMITTER: Zhao B
PROVIDER: S-EPMC4258123 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Zhao Bo B Wu Zizhen Z Grillet Nicolas N Yan Linxuan L Xiong Wei W Harkins-Perry Sarah S Müller Ulrich U
Neuron 20141120 5
Hair cells are the mechanosensory cells of the inner ear. Mechanotransduction channels in hair cells are gated by tip links. The molecules that connect tip links to transduction channels are not known. Here we show that the transmembrane protein TMIE forms a ternary complex with the tip-link component PCDH15 and its binding partner TMHS/LHFPL5. Alternative splicing of the PCDH15 cytoplasmic domain regulates formation of this ternary complex. Transducer currents are abolished by a homozygous Tmie ...[more]