Questioning the role of rebound firing in the cerebellum.
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ABSTRACT:
SUBMITTER: Alvina K
PROVIDER: S-EPMC2691662 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Publications
Questioning the role of rebound firing in the cerebellum.
Alviña Karina K Walter Joy T JT Kohn Adam A Ellis-Davies Graham G Khodakhah Kamran K
Nature neuroscience 20080928 11
A key component of recent theories on cerebellar function is rebound firing in neurons of the deep cerebellar nuclei (DCN). Despite the robustness of this phenomenon in vitro, in vivo studies have provided little evidence for its prevalence. We found that intact mouse or rat DCN neurons rarely showed rebound firing under physiological conditions in vitro or in vivo. These observations necessitate a critical re-evaluation of recent cerebellar models. ...[more]
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