Ontology highlight
ABSTRACT:
SUBMITTER: Teplyuk NM
PROVIDER: S-EPMC2691677 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Teplyuk Nadiya M NM Zhang Ying Y Lou Yang Y Hawse John R JR Hassan Mohammad Q MQ Teplyuk Viktor I VI Pratap Jitesh J Galindo Mario M Stein Janet L JL Stein Gary S GS Lian Jane B JB van Wijnen Andre J AJ
Molecular endocrinology (Baltimore, Md.) 20090402 6
Steroid hormones including (1,25)-dihydroxyvitamin D3, estrogens, and glucocorticoids control bone development and homeostasis. We show here that the osteogenic transcription factor Runx2 controls genes involved in sterol/steroid metabolism, including Cyp11a1, Cyp39a1, Cyp51, Lss, and Dhcr7 in murine osteoprogenitor cells. Cyp11a1 (P450scc) encodes an approximately 55-kDa mitochondrial enzyme that catalyzes side-chain cleavage of cholesterol and is rate limiting for steroid hormone biosynthesis. ...[more]