Ontology highlight
ABSTRACT:
SUBMITTER: Qiu P
PROVIDER: S-EPMC2691846 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Qiu Ping P Sanfiorenzo Vincent V Curry Stephanie S Guo Zhuyan Z Liu Shaotang S Skelton Angela A Xia Ellen E Cullen Constance C Ralston Robert R Greene Jonathan J Tong Xiao X
Nucleic acids research 20090424 10
A major challenge to successful antiviral therapy is the emergence of drug-resistant viruses. Recent studies have developed several automated analyses of HIV sequence polymorphism based on calculations of selection pressure (K(a)/K(s)) to predict drug resistance mutations. Similar resistance analysis programs for HCV inhibitors are not currently available. Taking advantage of the recently available sequence data of patient HCV samples from a Phase II clinical study of protease inhibitor boceprev ...[more]