Ontology highlight
ABSTRACT:
SUBMITTER: Nam JS
PROVIDER: S-EPMC2692258 | biostudies-literature | 2007 Nov
REPOSITORIES: biostudies-literature
Nam Ju-Suk JS Park Emily E Turcotte Taryn J TJ Palencia Servando S Zhan Xiaoming X Lee Jackie J Yun Kyuson K Funk Walter D WD Yoon Jeong Kyo JK
Developmental biology 20070817 1
The R-spondin (Rspo) family of proteins consists of secreted cysteine-rich proteins that can activate beta-catenin signaling via the Frizzled/LRP5/6 receptor complex. Here, we report that targeted inactivation of the mouse Rspo2 gene causes developmental limb defects, especially in the hindlimb. Although the initiation of the expression of apical ectodermal ridge (AER)-specific genes, including fibroblast growth factor 8 (FGF8) and FGF4 occurred normally, the maintenance of these marker expressi ...[more]