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Host switch during evolution of a genetically distinct hantavirus in the American shrew mole (Neurotrichus gibbsii).

ABSTRACT: A genetically distinct hantavirus, designated Oxbow virus (OXBV), was detected in tissues of an American shrew mole (Neurotrichus gibbsii), captured in Gresham, Oregon, in September 2003. Pairwise analysis of full-length S- and M- and partial L-segment nucleotide and amino acid sequences of OXBV indicated low sequence similarity with rodent-borne hantaviruses. Phylogenetic analyses using maximum-likelihood and Bayesian methods, and host-parasite evolutionary comparisons, showed that OXBV and Asama virus, a hantavirus recently identified from the Japanese shrew mole (Urotrichus talpoides), were related to soricine shrew-borne hantaviruses from North America and Eurasia, respectively, suggesting parallel evolution associated with cross-species transmission.

SUBMITTER: Kang HJ

PROVIDER: S-EPMC2692302 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature

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Host switch during evolution of a genetically distinct hantavirus in the American shrew mole (Neurotrichus gibbsii).

Kang Hae Ji HJ Bennett Shannon N SN Dizney Laurie L Sumibcay Laarni L Arai Satoru S Ruedas Luis A LA Song Jin-Won JW Yanagihara Richard R

Virology 20090423 1

A genetically distinct hantavirus, designated Oxbow virus (OXBV), was detected in tissues of an American shrew mole (Neurotrichus gibbsii), captured in Gresham, Oregon, in September 2003. Pairwise analysis of full-length S- and M- and partial L-segment nucleotide and amino acid sequences of OXBV indicated low sequence similarity with rodent-borne hantaviruses. Phylogenetic analyses using maximum-likelihood and Bayesian methods, and host-parasite evolutionary comparisons, showed that OXBV and Asa ...[more]

PMID: 19394994

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