Unknown

Dataset Information

0

Association of CYP1B1 haplotypes and breast cancer risk in Caucasian women.

ABSTRACT: CYP1B1 is a key enzyme involved in estrogen metabolism and may play an important role in the development and progression of breast cancer. In a population-based case-control study, we examined eight CYP1B1 haplotype-tagging single nucleotide polymorphisms in relation to invasive breast cancer risk. Analyses were based on 1,655 cases and 1,470 controls; all women were Caucasian. Among the individual single nucleotide polymorphisms, one (rs9341266) was associated with increased risk of breast cancer (P(trend) = 0.021), although the association was no longer significant after adjusting for multiple tests. A marginally significant haplotype effect was identified (P(global) = 0.015), with significant associations identified for 2 uncommon haplotypes comprising 4% of the controls. Results suggest that genetic variation in CYP1B1 has at most a minor influence on breast cancer susceptibility among Caucasian women.

SUBMITTER: Huang Y 

PROVIDER: S-EPMC2692636 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Association of CYP1B1 haplotypes and breast cancer risk in Caucasian women.

Huang Yifan Y   Trentham-Dietz Amy A   García-Closas Montserrat M   Newcomb Polly A PA   Titus-Ernstoff Linda L   Hampton John M JM   Chanock Stephen J SJ   Haines Jonathan L JL   Egan Kathleen M KM  

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20090317 4

CYP1B1 is a key enzyme involved in estrogen metabolism and may play an important role in the development and progression of breast cancer. In a population-based case-control study, we examined eight CYP1B1 haplotype-tagging single nucleotide polymorphisms in relation to invasive breast cancer risk. Analyses were based on 1,655 cases and 1,470 controls; all women were Caucasian. Among the individual single nucleotide polymorphisms, one (rs9341266) was associated with increased risk of breast canc  ...[more]

Similar Datasets

Unknown Association of COMT haplotypes and breast cancer risk in caucasian women.
| S-EPMC3086748 | biostudies-literature
Unknown ATM haplotypes and breast cancer risk in Jewish high-risk women.
| S-EPMC2361267 | biostudies-literature
Unknown A genome-wide scan for breast cancer risk haplotypes among African American women.
| S-EPMC3585353 | biostudies-literature
Unknown Association of VEGF haplotypes with breast cancer risk in North-West Indians.
| S-EPMC8386001 | biostudies-literature
Unknown Sex-Hormone-Binding Globulin Gene Polymorphisms and Breast Cancer Risk in Caucasian Women of Russia.
| S-EPMC10888713 | biostudies-literature
Unknown Whole Genome Transcriptome Analysis of the Association between Obesity and Triple-Negative Breast Cancer in Caucasian Women.
| S-EPMC6265882 | biostudies-literature
Unknown Association between lifetime exposure to passive smoking and risk of breast cancer subtypes defined by hormone receptor status among non-smoking Caucasian women.
| S-EPMC5289535 | biostudies-literature
Unknown Evaluation of CYP17A1 and CYP1B1 polymorphisms in male breast cancer risk.
| S-EPMC6733362 | biostudies-literature
Unknown Association studies of excision repair cross-complementation group 1 (ERCC1) haplotypes with lung and head and neck cancer risk in a Caucasian population.
| S-EPMC3081042 | biostudies-literature
Unknown Association of polymorphisms and haplotypes in the insulin-like growth factor 1 receptor (IGF1R) gene with the risk of breast cancer in Korean women.
| S-EPMC3879335 | biostudies-literature