Association of COMT haplotypes and breast cancer risk in caucasian women.
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ABSTRACT:
SUBMITTER: Peterson NB
PROVIDER: S-EPMC3086748 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Publications
Association of COMT haplotypes and breast cancer risk in caucasian women.
Peterson Neeraja B NB Trentham-Dietz Amy A Garcia-Closas Montserrat M Newcomb Polly A PA Titus-Ernstoff Linda L Huang Yifan Y Chanock Stephen J SJ Haines Jonathan L JL Egan Kathleen M KM
Anticancer research 20100101 1
Catechol-O-methyl transferase (COMT) is an important estrogen-metabolizing enzyme, and common genetic variants in this gene could affect breast cancer risk. We conducted a large population-based case control study in Massachusetts, New Hampshire, and Wisconsin to examine six strategically selected COMT haplotype-tagging (ht) single nucleotide polymorphism (SNPs), including the val158met polymorphism (rs4680), in relation to breast cancer risk. Analyses were based on 1,655 Caucasian women with in ...[more]
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