Ontology highlight
ABSTRACT:
SUBMITTER: Feng J
PROVIDER: S-EPMC2692702 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
The journals of gerontology. Series A, Biological sciences and medical sciences 20081101 11
Carbonylation is a highly prevalent protein modification in skeletal muscle mitochondria, possibly contributing to its functional decline with age. Using quantitative proteomics, we identified mitochondrial proteins susceptible to carbonylation in a muscle type (slow- vs fast-twitch)-dependent and age-dependent manner from Fischer 344 rat skeletal muscle. Fast-twitch muscle contained twice as many carbonylated mitochondrial proteins than did slow-twitch muscle, with 22 proteins showing significa ...[more]