Ontology highlight
ABSTRACT:
SUBMITTER: Raychaudhury S
PROVIDER: S-EPMC2693034 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Raychaudhury Suchismita S Farelli Jeremiah D JD Montminy Timothy P TP Matthews Miguelina M Ménétret Jean-François JF Duménil Guillaume G Roy Craig R CR Head James F JF Isberg Ralph R RR Akey Christopher W CW
Structure (London, England : 1993) 20090401 4
During infection, Legionella pneumophila creates a replication vacuole within eukaryotic cells and this requires a Type IVb secretion system (T4bSS). IcmQ plays a critical role in the translocase and associates with IcmR. In this paper, we show that the N-terminal domain of IcmQ (Qn) mediates self-dimerization, whereas the C-terminal domain with a basic linker promotes membrane association. In addition, the binding of IcmR to IcmQ prevents self-dimerization and also blocks membrane permeabilizat ...[more]