Unknown

Dataset Information

0

Genome-wide linkage of cotinine pharmacokinetics suggests candidate regions on chromosomes 9 and 11.

ABSTRACT: Characterizing cotinine pharmacokinetics is a useful way to study nicotine metabolism because the same liver enzyme is primarily responsible for the metabolism of both, and the clearances of nicotine and cotinine are highly correlated. We conducted a whole-genome linkage analysis to search for candidate regions influencing quantitative variation in cotinine pharmacokinetics in a large-scale pharmacokinetic study with 61 families containing 224 healthy adult participants. The strongest linkage signal was identified at 135 cM of chromosome 9 with LOD = 2.81 and P = 0.0002; two other suggestive linkage peaks appear at 31.4 and 73.5 cM of chromosome 11 with LOD = 1.96 (P = 0.0013) and 1.94 (P = 0.0014). The confidence level of the linkage between the three genome regions and cotinine pharmacokinetics is statistically significant with a genome-wide empirical probability of P = 0.029.

SUBMITTER: He Y 

PROVIDER: S-EPMC2693302 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Genome-wide linkage of cotinine pharmacokinetics suggests candidate regions on chromosomes 9 and 11.

He Yungang Y   Bergen Andrew W AW   Hops Hyman H   Andrews Judy A JA   Tildesley Elizabeth E   Lessov-Schlaggar Christina N CN   Webster Cris C   Benowitz Neal N   Swan Gary E GE  

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 20090601 4

Characterizing cotinine pharmacokinetics is a useful way to study nicotine metabolism because the same liver enzyme is primarily responsible for the metabolism of both, and the clearances of nicotine and cotinine are highly correlated. We conducted a whole-genome linkage analysis to search for candidate regions influencing quantitative variation in cotinine pharmacokinetics in a large-scale pharmacokinetic study with 61 families containing 224 healthy adult participants. The strongest linkage si  ...[more]

Similar Datasets

Unknown Were genome-wide linkage studies a waste of time? Exploiting candidate regions within genome-wide association studies.
| S-EPMC2811772 | biostudies-literature
Unknown Genome-wide linkage analysis of human auditory cortical activation suggests distinct loci on chromosomes 2, 3, and 8.
| S-EPMC6621440 | biostudies-literature
Unknown Genome-wide linkage scan of a pedigree with familial hypercholesterolemia suggests susceptibility loci on chromosomes 3q25-26 and 21q22.
| S-EPMC3194805 | biostudies-literature
Unknown Multicenter linkage study of schizophrenia candidate regions on chromosomes 5q, 6q, 10p, and 13q: schizophrenia linkage collaborative group III.
| S-EPMC1287525 | biostudies-literature
Unknown Genome-wide scan with nearly 700,000 SNPs in two Sardinian sub-populations suggests some regions as candidate targets for positive selection.
| S-EPMC3476709 | biostudies-literature
Unknown Genome-wide linkage screen in familial Parkinson disease identifies loci on chromosomes 3 and 18.
| S-EPMC2667976 | biostudies-literature
Unknown Genome-wide linkage study suggests a susceptibility locus for isolated bilateral microtia on 4p15.32-4p16.2.
| S-EPMC4077761 | biostudies-literature
Unknown Genome-Wide Linkage-Disequilibrium Mapping to the Candidate Gene Level in Melon (Cucumis melo).
| S-EPMC5575340 | biostudies-literature
Unknown Genome-wide parametric linkage analyses of 644 bipolar pedigrees suggest susceptibility loci at chromosomes 16 and 20.
| S-EPMC4418612 | biostudies-literature
Unknown A genome-wide sib-pair scan for quantitative language traits reveals linkage to chromosomes 10 and 13.
| S-EPMC4755290 | biostudies-literature