Ontology highlight
ABSTRACT:
SUBMITTER: Ma Z
PROVIDER: S-EPMC2693338 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Ma Zhidong Z Rao Lu L Bierbach Ulrich U
Journal of medicinal chemistry 20090501 10
The reactivity of two DNA-targeted platinum-acridine conjugates with cysteine sulfur was studied. The conjugate containing an amidine-NH donor group cis to the chloride leaving group showed considerably reduced reactivity with N-acetylcysteine compared to the prototypical derivative containing a thiourea-S linkage. The opposite scenario has been observed previously in reactions with nucleobase nitrogen. Possible consequences of the unique target-selective tuning of the substitution chemistry for ...[more]