Ontology highlight
ABSTRACT:
SUBMITTER: Graham LA
PROVIDER: S-EPMC3173770 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Graham Leigh A LA Wilson Gary M GM West Tiffany K TK Day Cynthia S CS Kucera Gregory L GL Bierbach Ulrich U
ACS medicinal chemistry letters 20110901 9
The formation of unusual seven-membered, sterically overloaded chelates [Pt(en)(L/L´)](NO(3))(2) (4a/4b) from the corresponding potent hybrid antitumor agents [PtCl(en)(LH/L´H)](NO(3))(2) (3a/3b) is described, where en is ethane-1,2-diamine and L(H) and L´(H) are (protonated) N-(2-(acridin-9-ylamino)ethyl)-N-methylpropionimidamide and N-(2-(acridin-9-ylamino)ethyl)-N-methylacetimidamide, respectively. Compounds 3a and 3b inhibit H460 lung cancer cell proliferation with IC(50) values of 12 ± 2 nM ...[more]