Ontology highlight
ABSTRACT:
SUBMITTER: Boomer JA
PROVIDER: S-EPMC2693366 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Boomer Jeremy A JA Qualls Marquita M MM Inerowicz H Dorota HD Haynes Robert H RH Patri V Srilakshmi VS Kim Jong-Mok JM Thompson David H DH
Bioconjugate chemistry 20090101 1
An acid-cleavable PEG lipid, 1'-(4'-cholesteryloxy-3'-butenyl)-omega-methoxy-polyethylene[112] glycolate (CVEP), has been developed that produces stable liposomes when dispersed as a minor component (0.5-5 mol %) in 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE). Cleavage of CVEP at mildly acidic pHs results in dePEGylation of the latently fusogenic DOPE liposomes, thereby triggering the onset of content release. This paper describes the synthesis of CVEP via a six-step sequence starting f ...[more]