Ontology highlight
ABSTRACT:
SUBMITTER: Kim BK
PROVIDER: S-EPMC4057673 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Kim Bieong-Kil BK Seu Young-Bae YB Bae Yun-Ui YU Kwak Tae-Won TW Kang Hyungu H Moon Ik-Jae IJ Hwang Guen-Bae GB Park So-Young SY Doh Kyung-Oh KO
International journal of molecular sciences 20140428 5
Cationic liposomes are broadly used as non-viral vectors to deliver genetic materials that can be used to treat various diseases including cancer. To circumvent problems associated with cationic liposome-mediated delivery systems such as low transfection efficiency and serum-induced inhibition, cholesterol-based cationic lipids have been synthesized that resist the effects of serum. The introduction of an ether-type linkage and extension of the aminopropyl head group on the cholesterol backbone ...[more]