Epigenetic regulation of HIV-1 latency by cytosine methylation.
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ABSTRACT:
SUBMITTER: Kauder SE
PROVIDER: S-EPMC2695767 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Publications
Epigenetic regulation of HIV-1 latency by cytosine methylation.
Kauder Steven E SE Bosque Alberto A Lindqvist Annica A Planelles Vicente V Verdin Eric E
PLoS pathogens 20090626 6
Human immunodeficiency virus type 1 (HIV-1) persists in a latent state within resting CD4+ T cells of infected persons treated with highly active antiretroviral therapy (HAART). This reservoir must be eliminated for the clearance of infection. Using a cDNA library screen, we have identified methyl-CpG binding domain protein 2 (MBD2) as a regulator of HIV-1 latency. Two CpG islands flank the HIV-1 transcription start site and are methylated in latently infected Jurkat cells and primary CD4+ T cel ...[more]
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