Epigenetic heterogeneity in HIV-1 latency establishment.
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ABSTRACT:
SUBMITTER: Matsuda Y
PROVIDER: S-EPMC4287722 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Publications
Epigenetic heterogeneity in HIV-1 latency establishment.
Matsuda Yuka Y Kobayashi-Ishihara Mie M Fujikawa Dai D Ishida Takaomi T Watanabe Toshiki T Yamagishi Makoto M
Scientific reports 20150109
Despite prolonged antiretroviral therapy, HIV-1 persists as transcriptionally inactive proviruses. The HIV-1 latency remains a principal obstacle in curing AIDS. It is important to understand mechanisms by which HIV-1 latency is established to make the latent reservoir smaller. We present a molecular characterization of distinct populations at an early phase of infection. We developed an original dual-color reporter virus to monitor LTR kinetics from establishment to maintenance stage. We found ...[more]
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