Normal human aging and early-stage schizophrenia share common molecular profiles.
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ABSTRACT:
SUBMITTER: Tang B
PROVIDER: S-EPMC2695825 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Publications
Normal human aging and early-stage schizophrenia share common molecular profiles.
Tang Bin B Chang Wei-li WL Lanigan Caroline M CM Dean Brian B Sutcliffe J Gregor JG Thomas Elizabeth A EA
Aging cell 20090226 3
We examined genome-wide expression datasets from human prefrontal cortex of normal and schizophrenic individuals ranging from 19 to 81 years of age. We found that changes in gene expression that are correlated with aging in normal subjects differ dramatically from those observed with aging in schizophrenic subjects. Only 2.5% of genes were correlated with age in both groups. Surprisingly, we also found a significant overlap (29-34%) between those genes whose expression was correlated with aging ...[more]
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