Tumor suppressor and hepatocellular carcinoma.
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ABSTRACT:
SUBMITTER: Martin J
PROVIDER: S-EPMC2695912 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Publications
Tumor suppressor and hepatocellular carcinoma.
Martin Juliette J Dufour Jean-Francois JF
World journal of gastroenterology 20080301 11
A few signaling pathways are driving the growth of hepatocellular carcinoma. Each of these pathways possesses negative regulators. These enzymes, which normally suppress unchecked cell proliferation, are circumvented in the oncogenic process, either the over-activity of oncogenes is sufficient to annihilate the activity of tumor suppressors or tumor suppressors have been rendered ineffective. The loss of several key tumor suppressors has been described in hepatocellular carcinoma. Here, we syste ...[more]
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