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Tumor suppressor and hepatocellular carcinoma.

ABSTRACT: A few signaling pathways are driving the growth of hepatocellular carcinoma. Each of these pathways possesses negative regulators. These enzymes, which normally suppress unchecked cell proliferation, are circumvented in the oncogenic process, either the over-activity of oncogenes is sufficient to annihilate the activity of tumor suppressors or tumor suppressors have been rendered ineffective. The loss of several key tumor suppressors has been described in hepatocellular carcinoma. Here, we systematically review the evidence implicating tumor suppressors in the development of hepatocellular carcinoma.

SUBMITTER: Martin J

PROVIDER: S-EPMC2695912 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature

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Tumor suppressor and hepatocellular carcinoma.

Martin Juliette J Dufour Jean-Francois JF

World journal of gastroenterology 20080301 11

A few signaling pathways are driving the growth of hepatocellular carcinoma. Each of these pathways possesses negative regulators. These enzymes, which normally suppress unchecked cell proliferation, are circumvented in the oncogenic process, either the over-activity of oncogenes is sufficient to annihilate the activity of tumor suppressors or tumor suppressors have been rendered ineffective. The loss of several key tumor suppressors has been described in hepatocellular carcinoma. Here, we syste ...[more]

PMID: 18350603

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