Ontology highlight
ABSTRACT:
SUBMITTER: Song WH
PROVIDER: S-EPMC4847826 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Song Wei-Hua WH Feng Xiao-Jun XJ Gong Shao-Juan SJ Chen Jian-Ming JM Wang Shou-Mei SM Xing Dong-Juan DJ Zhu Ming-Hua MH Zhang Shu-Hui SH Xu Ai-Min AM
Cancer biology & therapy 20150101 12
microRNAs (miRNAs) are important regulators of tumor development and progression. In this study, we aimed to explore the expression and role of miR-622 in hepatocellular carcinoma (HCC). We found that miR-622 was significantly downregulated in human HCC specimens compared to adjacent noncancerous liver tissues. miR-622 downregulation was significantly associated with aggressive parameters and poor prognosis in HCC. Enforced expression of miR-622 significantly decreased the proliferation and colo ...[more]