Ontology highlight
ABSTRACT:
SUBMITTER: Yang J
PROVIDER: S-EPMC2695938 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Yang Junbao J Gebe John A JA Huston Laurie L James Eddie E Tan Venus V Yue Betty B BB Nepom Gerald T GT Kwok William W WW
Vaccine 20090503 29
CD4+ T cells play a pivotal role in the viral immunity, and as such identification of unique strain-specific HLA class II restricted epitopes is essential for monitoring cellular strain-specific viral immunity. Using Tetramer-Guided Epitope Mapping technique, we identified HLA-DR0401 restricted HA epitopes that are strain-specific to H5N1 virion. Two immunodominant epitopes H5HA(441-460) and H5HA(57-76) were identified from in vitro stimulated human PBMC. Both epitopes elicit strong cellular imm ...[more]