Ontology highlight
ABSTRACT:
SUBMITTER: Kloverpris HN
PROVIDER: S-EPMC4347545 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Kløverpris Henrik N HN Cole David K DK Fuller Anna A Carlson Jonathan J Beck Konrad K Schauenburg Andrea J AJ Rizkallah Pierre J PJ Buus Søren S Sewell Andrew K AK Goulder Philip P
Retrovirology 20150220
<h4>Background</h4>Presentation of identical HIV-1 peptides by closely related Human Leukocyte Antigen class I (HLAI) molecules can select distinct patterns of escape mutation that have a significant impact on viral fitness and disease progression. The molecular mechanisms by which HLAI micropolymorphisms can induce differential HIV-1 escape patterns within identical peptide epitopes remain unknown.<h4>Results</h4>Here, we undertook genetic and structural analyses of two immunodominant HIV-1 pep ...[more]