Ontology highlight
ABSTRACT:
SUBMITTER: Menna E
PROVIDER: S-EPMC2696597 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Menna Elisabetta E Disanza Andrea A Cagnoli Cinzia C Schenk Ursula U Gelsomino Giuliana G Frittoli Emanuela E Hertzog Maud M Offenhauser Nina N Sawallisch Corinna C Kreienkamp Hans-Jürgen HJ Gertler Frank B FB Di Fiore Pier Paolo PP Scita Giorgio G Matteoli Michela M
PLoS biology 20090630 6
The regulation of filopodia plays a crucial role during neuronal development and synaptogenesis. Axonal filopodia, which are known to originate presynaptic specializations, are regulated in response to neurotrophic factors. The structural components of filopodia are actin filaments, whose dynamics and organization are controlled by ensembles of actin-binding proteins. How neurotrophic factors regulate these latter proteins remains, however, poorly defined. Here, using a combination of mouse gene ...[more]