Ontology highlight
ABSTRACT:
SUBMITTER: Turlova E
PROVIDER: S-EPMC4820394 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Turlova Ekaterina E Bae Christine Y J CYJ Deurloo Marielle M Chen Wenliang W Barszczyk Andrew A Horgen F David FD Fleig Andrea A Feng Zhong-Ping ZP Sun Hong-Shuo HS
Molecular neurobiology 20141211 1
Transient receptor potential melastatin 7 (TRPM7) is a calcium-permeable divalent cation channel and mediates neuronal cell death under ischemic stresses. In this study, we investigated the contribution of TRPM7 to neuronal development in mouse primary hippocampal neurons. We demonstrated that TRPM7 channels are highly expressed in the tips of the growth cone. Either knockdown of TRPM7 with target-specific shRNA or blocking channel conductance by a specific blocker waixenicin A enhanced axonal o ...[more]