Ontology highlight
ABSTRACT:
SUBMITTER: Ding Y
PROVIDER: S-EPMC2697446 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
Ding Yousong Y Seufert Wolfgang H WH Beck Zachary Q ZQ Sherman David H DH
Journal of the American Chemical Society 20080326 16
Cryptophycins are potent anticancer agents isolated from Nostoc sp. ATCC 53789 and Nostoc sp. GSV 224. The most potent natural cryptophycin analogues retain a beta-epoxide at the C2'-C3' position of the molecule. A P450 epoxidase encoded by c rpE recently identified from the cryptophycin gene cluster was shown to install this key functional group into cryptophycin-4 (Cr-4) to produce cryptophycin-2 (Cr-2) in a regio- and stereospecific manner. Here we report a detailed characterization of the Cr ...[more]