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Action potentials contribute to neuronal signaling in C. elegans.

ABSTRACT: Small, high-impedance neurons with short processes, similar to those found in the soil nematode Caenorhabditis elegans, are predicted to transmit electrical signals by passive propagation. However, we have found that certain neurons in C. elegans fire regenerative action potentials. These neurons resembled Schmitt triggers, as their potential state appears to be bistable. Transitions between up and down states could be triggered by application of the neurotransmitter glutamate or brief current pulses.

SUBMITTER: Mellem JE 

PROVIDER: S-EPMC2697921 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature

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Action potentials contribute to neuronal signaling in C. elegans.

Mellem Jerry E JE   Brockie Penelope J PJ   Madsen David M DM   Maricq Andres V AV  

Nature neuroscience 20080629 8

Small, high-impedance neurons with short processes, similar to those found in the soil nematode Caenorhabditis elegans, are predicted to transmit electrical signals by passive propagation. However, we have found that certain neurons in C. elegans fire regenerative action potentials. These neurons resembled Schmitt triggers, as their potential state appears to be bistable. Transitions between up and down states could be triggered by application of the neurotransmitter glutamate or brief current p  ...[more]

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