Ontology highlight
ABSTRACT:
SUBMITTER: Navarro MA
PROVIDER: S-EPMC7043890 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Navarro Marco A MA Salari Autoosa A Lin Jenna L JL Cowan Luke M LM Penington Nicholas J NJ Milescu Mirela M Milescu Lorin S LS
eLife 20200226
Voltage-gated sodium channels play a critical role in cellular excitability, amplifying small membrane depolarizations into action potentials. Interactions with auxiliary subunits and other factors modify the intrinsic kinetic mechanism to result in new molecular and cellular functionality. We show here that sodium channels can implement a molecular leaky integrator, where the input signal is the membrane potential and the output is the occupancy of a long-term inactivated state. Through this me ...[more]