CX3CR1+ CD115+ CD135+ common macrophage/DC precursors and the role of CX3CR1 in their response to inflammation.
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ABSTRACT:
SUBMITTER: Auffray C
PROVIDER: S-EPMC2699130 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Publications
CX3CR1+ CD115+ CD135+ common macrophage/DC precursors and the role of CX3CR1 in their response to inflammation.
Auffray Cedric C Fogg Darin K DK Narni-Mancinelli Emilie E Senechal Brigitte B Trouillet Celine C Saederup Noah N Leemput Julia J Bigot Karine K Campisi Laura L Abitbol Marc M Molina Thierry T Charo Israel I Hume David A DA Cumano Ana A Lauvau Gregoire G Geissmann Frederic F
The Journal of experimental medicine 20090309 3
CX(3)CR1 expression is associated with the commitment of CSF-1R(+) myeloid precursors to the macrophage/dendritic cell (DC) lineage. However, the relationship of the CSF-1R(+) CX(3)CR1(+) macrophage/DC precursor (MDP) with other DC precursors and the role of CX(3)CR1 in macrophage and DC development remain unclear. We show that MDPs give rise to conventional DCs (cDCs), plasmacytoid DCs (PDCs), and monocytes, including Gr1(+) inflammatory monocytes that differentiate into TipDCs during infection ...[more]
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