Ontology highlight
ABSTRACT:
SUBMITTER: Roozendaal R
PROVIDER: S-EPMC2699624 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Roozendaal Ramon R Mempel Thorsten R TR Pitcher Lisa A LA Gonzalez Santiago F SF Verschoor Admar A Mebius Reina E RE von Andrian Ulrich H UH Carroll Michael C MC
Immunity 20090129 2
To track drainage of lymph-borne small and large antigens (Ags) into the peripheral lymph nodes and subsequent encounter by B cells and follicular dendritic cells, we used the approach of multiphoton intravital microscopy. We find a system of conduits that extend into the follicles and mediate delivery of small antigens to cognate B cells and follicular dendritic cells. The follicular conduits provide an efficient and rapid mechanism for delivery of small antigens and chemokines such as CXCL13 t ...[more]