Ontology highlight
ABSTRACT:
SUBMITTER: Salajegheh M
PROVIDER: S-EPMC2700211 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Salajegheh Mohammad M Pinkus Jack L JL Taylor J Paul JP Amato Anthony A AA Nazareno Remedios R Baloh Robert H RH Greenberg Steven A SA
Muscle & nerve 20090701 1
The nucleic acid binding protein TDP-43 was recently identified in normal myonuclei and in the sarcoplasm of inclusion body myositis (IBM) muscle. Here we found TDP-43 sarcoplasmic immunoreactivity in 23% of IBM myofibers, while other reported IBM biomarkers were less frequent, with rimmed vacuoles in 2.8%, fluorescent Congo red material in 0.57%, SMI-31 immunoreactivity in 0.83%, and focal R1282 beta-amyloid immunoreactivity in 0.00% of myofibers. The presence of as little as >1% of myofibers w ...[more]